› 3tn2

X-ray diffraction
1.6Å resolution

structure analysis of MIP1-beta P8A

Released:
DOI: 10.2210/pdb3tn2/pdb
PDB entry 3tn2 coloured by chain, front view.
PDB entry 3tn2 coloured by chain, side view.
PDB entry 3tn2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme.
Liang WG, Ren M, Zhao F, Tang WJ
J Mol Biol 427 1345-1358 (2015)
PMID: 25636406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-146517 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-C motif chemokine 4 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13236 (Residues: 24-91; Coverage: 99%)
Gene names: CCL4, LAG1, MIP1B, SCYA4
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

1 bound ligand:
Ligand ZN 3 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 51.062Å b: 36.972Å c: 31.061Å
α: 90° β: 108.54° γ: 90°
R-values:
R R work R free
0.159 0.157 0.199
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

CCL18 in the Progression of Cancer.
Korbecki et al. (2020)
7 more

6 mentions without citation

Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3.
Liang et al. (2016)
5 more