› 3tuh

X-ray diffraction
1.8Å resolution

Crystal Structure of the N-terminal domain of an HSP90 in the presence of an the inhibitor ganetespib

Released:
DOI: 10.2210/pdb3tuh/pdb
PDB entry 3tuh coloured by chain, front view.
PDB entry 3tuh coloured by chain, side view.
PDB entry 3tuh coloured by chain, top view.
Source organism: Homo sapiens
Entry author: Ying W

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139817 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Heat shock protein HSP 90-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 209 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P07900 (Residues: 16-224; Coverage: 29%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain

Ligands and Environments

1 bound ligand:
Ligand TUH 2 x TUH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21
Unit cell:
a: 56.362Å b: 88.878Å c: 56.498Å
α: 90° β: 99.41° γ: 90°
R-values:
R R work R free
0.172 0.172 0.212
Expression system: Not provided

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