› 3tvc

X-ray diffraction
2.43Å resolution

Human MMP13 in complex with L-glutamate motif inhibitor

Released:
DOI: 10.2210/pdb3tvc/pdb
PDB entry 3tvc coloured by chain, front view.
PDB entry 3tvc coloured by chain, side view.
PDB entry 3tvc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
Devel L, Beau F, Amoura M, Vera L, Cassar-Lajeunesse E, Garcia S, Czarny B, Stura EA, Dive V
J Biol Chem 287 26647-56 (2012)
PMID: 22689580

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155286 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Collagenase 3 Chain: A
Molecule details ›
Chain: A
Length: 169 amino acids
Theoretical weight: 19.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P45452 (Residues: 104-272; Coverage: 37%)
Gene name: MMP13
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments

4 bound ligands:
Ligand ZN 2 x ZN
Ligand CA 3 x CA
Ligand E3P 1 x E3P
Ligand PEG 3 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 60.303Å b: 85.16Å c: 40.916Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.165 0.162 0.234
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Matrix metalloproteinases as breast cancer drivers and therapeutic targets.
Radisky et al. (2015)
5 more

4 mentions without citation

Simple pseudo-dipeptides with a P2' glutamate: a novel inhibitor family of matrix metalloproteases and other metzincins.
Devel et al. (2012)
3 more