› 3txo

X-ray diffraction
2.05Å resolution

PKC eta kinase in complex with a naphthyridine

Released:
DOI: 10.2210/pdb3txo/pdb
PDB entry 3txo coloured by chain, front view.
PDB entry 3txo coloured by chain, side view.
PDB entry 3txo coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.
van Eis MJ, Evenou JP, Floersheim P, Gaul C, Cowan-Jacob SW, Monovich L, Rummel G, Schuler W, Stark W, Strauss A, von Matt A, Vangrevelinghe E, Wagner J, Soldermann N
Bioorg Med Chem Lett 21 7367-72 (2011)
PMID: 22078216

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-150275 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein kinase C eta type Chain: A
Molecule details ›
Chain: A
Length: 353 amino acids
Theoretical weight: 40.49 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24723 (Residues: 333-683; Coverage: 51%)
Gene names: PKCL, PRKCH, PRKCL
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 07U 1 x 07U
1 modified residue:
Ligand TPO 1 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21212
Unit cell:
a: 113.533Å b: 56.861Å c: 63.367Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.194 0.241
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Dynamics and Membrane Interactions of Protein Kinase C.
Igumenova TI. (2015)
1 more

8 mentions without citation

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.
Gógl et al. (2019)
7 more