› 3u0d

X-ray diffraction
2.51Å resolution

The structure of human Siderocalin bound to the bacterial siderophore 2,3-DHBA

Released:
DOI: 10.2210/pdb3u0d/pdb
PDB entry 3u0d coloured by chain, front view.
PDB entry 3u0d coloured by chain, side view.
PDB entry 3u0d coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines.
Correnti C, Richardson V, Sia AK, Bandaranayake AD, Ruiz M, Suryo Rahmanto Y, Kovačević Ž, Clifton MC, Holmes MA, Kaiser BK, Barasch J, Raymond KN, Richardson DR, Strong RK
PLoS One 7 e43696 (2012)
PMID: 22928018

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160356 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil gelatinase-associated lipocalin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 198 amino acids
Theoretical weight: 22.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P80188 (Residues: 1-198; Coverage: 100%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand FE 4 x FE
Ligand DBH 12 x DBH
Ligand CL 3 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 117.476Å b: 116.452Å c: 120.194Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.251 0.247 0.288
Expression system: Escherichia coli BL21(DE3)

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Citations

14 review citations

Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
Xiao et al. (2017)
13 more

2 mentions without citation

Siderocalin/Lcn2/NGAL/24p3 does not drive apoptosis through gentisic acid mediated iron withdrawal in hematopoietic cell lines.
Correnti et al. (2012)
1 more