› 3u0t

X-ray diffraction
2.5Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209162 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ponezumab LC Fab Chains: A, C
Molecule details ›
Chains: A, C
Length: 219 amino acids
Theoretical weight: 24.17 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
ponezumab HC Fab Chains: B, D
Molecule details ›
Chains: B, D
Length: 217 amino acids
Theoretical weight: 23.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
P3(40) Chains: E, F
Molecule details ›
Chains: E, F
Length: 11 amino acids
Theoretical weight: 1.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 701-711; Coverage: 2%)
Gene names: A4, AD1, APP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P21
Unit cell:
a: 83.37Å b: 64.25Å c: 95.89Å
α: 90° β: 112.42° γ: 90°
R-values:
R R work R free
0.22 0.219 0.268
Expression systems:
  • Homo sapiens
  • Not provided

Quick links

Citations

39 review citations

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy.
McGeer et al. (2013)
38 more

6 mentions without citation

Conformational selection in amyloid-based immunotherapy: Survey of crystal structures of antibody-amyloid complexes.
Ma et al. (2016)
5 more