› 3u2i

X-ray diffraction
1.7Å resolution

X-ray crystal structure of human Transthyretin at room temperature

Released:
DOI: 10.2210/pdb3u2i/pdb
PDB entry 3u2i coloured by chain, front view.
PDB entry 3u2i coloured by chain, side view.
PDB entry 3u2i coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Hydrogen-bond network and pH sensitivity in transthyretin: Neutron crystal structure of human transthyretin.
Yokoyama T, Mizuguchi M, Nabeshima Y, Kusaka K, Yamada T, Hosoya T, Ohhara T, Kurihara K, Tomoyori K, Tanaka I, Niimura N
J Struct Biol 177 283-90 (2012)
PMID: 22248451

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 117 amino acids
Theoretical weight: 12.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 32-147; Coverage: 91%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P21212
Unit cell:
a: 43.431Å b: 86.368Å c: 65.716Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.239
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Molecular mechanisms of disease-causing missense mutations.
Stefl et al. (2013)
7 more

4 mentions without citation

Large-volume protein crystal growth for neutron macromolecular crystallography.
Ng et al. (2015)
3 more