› 3u3v

X-ray diffraction
2.96Å resolution

The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)

Released:
DOI: 10.2210/pdb3u3v/pdb
PDB entry 3u3v coloured by chain, front view.
PDB entry 3u3v coloured by chain, side view.
PDB entry 3u3v coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.
Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ
Acta Crystallogr D Biol Crystallogr 68 521-30 (2012)
PMID: 22525750

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131002 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 21 Chain: A
Molecule details ›
Chain: A
Length: 313 amino acids
Theoretical weight: 34.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75509 (Residues: 42-348; Coverage: 50%)
Gene names: DR6, TNFRSF21, UNQ437/PRO868
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-1A
Spacegroup: P6122
Unit cell:
a: 77.778Å b: 77.778Å c: 187.642Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.192 0.257
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Principles of antibody-mediated TNF receptor activation.
Wajant H. (2015)
2 more

1 mention without citation

S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.
Ru et al. (2012)