3u82

X-ray diffraction
3.16Å resolution

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-172232 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Envelope glycoprotein D Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 32.48 KDa
Source organism: Human alphaherpesvirus 1 strain 17
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q69091 (Residues: 26-310; Coverage: 77%)
Gene names: US6, gD
Sequence domains: Herpesvirus glycoprotein D/GG/GX domain
Structure domains: Glycoprotein D; Chain: A;
Nectin-1 Chain: B
Molecule details ›
Chain: B
Length: 317 amino acids
Theoretical weight: 35.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15223 (Residues: 30-335; Coverage: 63%)
Gene names: HVEC, NECTIN1, PRR1, PVRL1
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2221
Unit cell:
a: 52.532Å b: 169.043Å c: 183.316Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.322 0.321 0.344
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli