› 3u9w

X-ray diffraction
1.25Å resolution

Structure of human Leukotriene A4 hydrolase in complex with inhibitor sc57461A

Released:
DOI: 10.2210/pdb3u9w/pdb
PDB entry 3u9w coloured by chain, front view.
PDB entry 3u9w coloured by chain, side view.
PDB entry 3u9w coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Niegowski D, Thunnissen M, Tholander F, Rinaldo-Matthis A, Muroya A, Haeggstrom JZ

Function and Biology Details

Reactions catalysed: 
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
Release of the N-terminal residue from a tripeptide.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Leukotriene A-4 hydrolase Chain: A
Molecule details ›
Chain: A
Length: 608 amino acids
Theoretical weight: 69.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09960 (Residues: 4-611; Coverage: 100%)
Gene names: LTA4, LTA4H
Sequence domains:
Structure domains:

Ligands and Environments

7 bound ligands:
Ligand ZN 1 x ZN
Ligand YB 8 x YB
Ligand CL 2 x CL
Ligand IMD 3 x IMD
Ligand GOL 1 x GOL
Ligand 28P 1 x 28P
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-2
Spacegroup: P212121
Unit cell:
a: 78.078Å b: 86.799Å c: 99.145Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.134 0.134 0.161
Expression system: Escherichia coli

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