› 3ued

X-ray diffraction
2.7Å resolution

Crystal structure of human Survivin bound to histone H3 phosphorylated on threonine-3 (C2 space group).

Released:
DOI: 10.2210/pdb3ued/pdb
PDB entry 3ued coloured by chain, front view.
PDB entry 3ued coloured by chain, side view.
PDB entry 3ued coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.
Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT
Mol Biol Cell 23 1457-66 (2012)
PMID: 22357620

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127463 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Baculoviral IAP repeat-containing protein 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 146 amino acids
Theoretical weight: 16.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
N-terminal fragment of histone H3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 12 amino acids
Theoretical weight: 1.39 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: C2
Unit cell:
a: 113.415Å b: 71.276Å c: 83.136Å
α: 90° β: 129.91° γ: 90°
R-values:
R R work R free
0.195 0.192 0.241
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

11 review citations

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
Carmena et al. (2012)
10 more

3 mentions without citation

Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.
Niedzialkowska et al. (2012)
2 more