› 3uf4

X-ray diffraction
1.98Å resolution

Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution

Released:
DOI: 10.2210/pdb3uf4/pdb
PDB entry 3uf4 coloured by chain, front view.
PDB entry 3uf4 coloured by chain, side view.
PDB entry 3uf4 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153932 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase Fyn Chain: A
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.88 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P39688 (Residues: 82-244; Coverage: 30%)
Gene name: Fyn
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand CL 2 x CL
Ligand GOL 2 x GOL
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2
Unit cell:
a: 138.22Å b: 35.96Å c: 43.96Å
α: 90° β: 93.56° γ: 90°
R-values:
R R work R free
0.201 0.2 0.224
Expression system: Escherichia coli

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