› 3uiu

X-ray diffraction
2.9Å resolution

Crystal structure of Apo-PKR kinase domain

Released:
DOI: 10.2210/pdb3uiu/pdb
PDB entry 3uiu coloured by chain, front view.
PDB entry 3uiu coloured by chain, side view.
PDB entry 3uiu coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Li F, Li S, Yang X, Shen Y, Zhang T

Function and Biology Details

Reactions catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148630 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced, double-stranded RNA-activated protein kinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 35.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19525 (Residues: 254-551; Coverage: 54%)
Gene names: EIF2AK2, PKR, PRKR
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3112
Unit cell:
a: 95.412Å b: 95.412Å c: 122.019Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.247 0.24 0.305
Expression system: Escherichia coli

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