› 3ukm

X-ray diffraction
3.4Å resolution

Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1)

Released:
DOI: 10.2210/pdb3ukm/pdb
PDB entry 3ukm coloured by chain, front view.
PDB entry 3ukm coloured by chain, side view.
PDB entry 3ukm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the human two-pore domain potassium channel K2P1.
Miller AN, Long SB
Science 335 432-6 (2012)
PMID: 22282804

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126136 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel subfamily K member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 280 amino acids
Theoretical weight: 31.91 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O00180 (Residues: 19-288; Coverage: 80%)
Gene names: HOHO1, KCNK1, KCNO1, TWIK1
Sequence domains: Ion channel
Structure domains: Helix Hairpins

Ligands and Environments

2 bound ligands:
Ligand UND 4 x UND
Ligand K 10 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 82.08Å b: 123.171Å c: 119.305Å
α: 90° β: 94.91° γ: 90°
R-values:
R R work R free
0.273 0.273 0.279
Expression system: Komagataella pastoris

Quick links

Citations

48 review citations

Mechanically Activated Ion Channels.
Ranade et al. (2015)
47 more

35 mentions without citation

Hydrophobic gating in ion channels.
Aryal et al. (2015)
34 more