› 3ukx

X-ray diffraction
2.2Å resolution

Mouse importin alpha: Bimax2 peptide complex

Released:
DOI: 10.2210/pdb3ukx/pdb
PDB entry 3ukx coloured by chain, front view.
PDB entry 3ukx coloured by chain, side view.
PDB entry 3ukx coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis of high-affinity nuclear localization signal interactions with importin-α.
Marfori M, Lonhienne TG, Forwood JK, Kobe B
Traffic 13 532-48 (2012)
PMID: 22248489

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156507 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit alpha-1 Chain: B
Molecule details ›
Chain: B
Length: 510 amino acids
Theoretical weight: 55.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P52293 (Residues: 70-529; Coverage: 87%)
Gene names: Kpna2, Rch1
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Bimax2 peptide Chain: C
Molecule details ›
Chain: C
Length: 28 amino acids
Theoretical weight: 3.72 KDa
Source organism: Mus musculus
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX1
Spacegroup: P212121
Unit cell:
a: 79.187Å b: 90.187Å c: 100.221Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.178 0.203
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

9 review citations

Broad targeting of resistance to apoptosis in cancer.
Mohammad et al. (2015)
8 more

5 mentions without citation

Design rules for selective binding of nuclear localization signals to minor site of importin α.
Pang et al. (2014)
4 more