› 3un9

X-ray diffraction
2.65Å resolution

Crystal structure of an immune receptor

Released:
DOI: 10.2210/pdb3un9/pdb
PDB entry 3un9 coloured by chain, front view.
PDB entry 3un9 coloured by chain, side view.
PDB entry 3un9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure and functional characterization of the RNA-binding element of the NLRX1 innate immune modulator.
Hong M, Yoon SI, Wilson IA
Immunity 36 337-47 (2012)
PMID: 22386589

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183188 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NLR family member X1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 372 amino acids
Theoretical weight: 40.62 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q86UT6 (Residues: 629-975; Coverage: 36%)
Gene names: NLRX1, NOD5, NOD9
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:
Ligand PT 4 x PT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: C2221
Unit cell:
a: 99.011Å b: 123.469Å c: 145.848Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.223 0.267
Expression system: Trichoplusia ni

Quick links

Citations

30 review citations

Cytosolic sensing of viruses.
Goubau et al. (2013)
29 more

10 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
9 more