› 3unm

X-ray diffraction
1.8Å resolution

Crystal Structure of The Human MDC1 FHA Domain

Released:
DOI: 10.2210/pdb3unm/pdb
PDB entry 3unm coloured by chain, front view.
PDB entry 3unm coloured by chain, side view.
PDB entry 3unm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.
Liu J, Luo S, Zhao H, Liao J, Li J, Yang C, Xu B, Stern DF, Xu X, Ye K
Nucleic Acids Res 40 3898-912 (2012)
PMID: 22234877

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172077 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mediator of DNA damage checkpoint protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 113 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14676 (Residues: 27-138; Coverage: 5%)
Gene names: KIAA0170, MDC1, NFBD1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 30.651Å b: 56.053Å c: 64.92Å
α: 90° β: 97.53° γ: 90°
R-values:
R R work R free
0.236 0.234 0.274
Expression system: Escherichia coli

Quick links

Citations

10 review citations

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response.
Blackford et al. (2017)
9 more

1 mention without citation

Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain.
Liu et al. (2012)