3unn

X-ray diffraction
1.7Å resolution

Monomeric structure of the human MDC1 FHA domain in complex with an MDC1 phospho-T4 peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-172075 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mediator of DNA damage checkpoint protein 1 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 12.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14676 (Residues: 27-138; Coverage: 5%)
Gene names: KIAA0170, MDC1, NFBD1
Sequence domains: FHA domain
Structure domains: Tumour Suppressor Smad4
Mediator of DNA damage checkpoint protein 1 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q14676 (Residues: 1-8; Coverage: 0%)
Gene names: KIAA0170, MDC1, NFBD1

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P3121
Unit cell:
a: 52.935Å b: 52.935Å c: 81.241Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.207 0.232
Expression systems:
  • Escherichia coli
  • Not provided