› 3uwn

X-ray diffraction
2.15Å resolution

The 3-MBT repeat domain of L3MBTL1 in complex with a methyl-lysine mimic

Released:
DOI: 10.2210/pdb3uwn/pdb
PDB entry 3uwn coloured by chain, front view.
PDB entry 3uwn coloured by chain, side view.
PDB entry 3uwn coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Zhong N, Tempel W, Wernimont AK, Graslund S, Ingerman LA, Korboukh V, Kireev DB, Gao C, Frye SV, Arrowsmith CH, Edwards AM, Bountra C, Weigelt J, Brown PJ, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lethal(3)malignant brain tumor-like protein 1 Chain: A
Molecule details ›
Chain: A
Length: 331 amino acids
Theoretical weight: 37.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9Y468 (Residues: 268-598; Coverage: 39%)
Gene names: KIAA0681, L3MBT, L3MBTL, L3MBTL1
Sequence domains: mbt repeat
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand UWN 1 x UWN
Ligand UNX 14 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P21212
Unit cell:
a: 85.774Å b: 94.53Å c: 58.955Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.231 0.267
Expression system: Escherichia coli BL21

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