› 3uys

X-ray diffraction
2.3Å resolution

Crystal structure of apo human ck1d

Released:
DOI: 10.2210/pdb3uys/pdb
PDB entry 3uys coloured by chain, front view.
PDB entry 3uys coloured by chain, side view.
PDB entry 3uys coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
Long A, Zhao H, Huang X
J Med Chem 55 956-60 (2012)
PMID: 22168824

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand SO4 10 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 49.77Å b: 85.16Å c: 89.12Å
α: 70.19° β: 73.86° γ: 86.15°
R-values:
R R work R free
0.238 0.238 0.276
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
Xu et al. (2019)
4 more

4 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
3 more