› 3uyt

X-ray diffraction
2Å resolution

crystal structure of ck1d with PF670462 from P1 crystal form

Released:
DOI: 10.2210/pdb3uyt/pdb
PDB entry 3uyt coloured by chain, front view.
PDB entry 3uyt coloured by chain, side view.
PDB entry 3uyt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
Long A, Zhao H, Huang X
J Med Chem 55 956-60 (2012)
PMID: 22168824

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 0CK 4 x 0CK
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 49.15Å b: 85.34Å c: 89.14Å
α: 72.87° β: 74.36° γ: 87.26°
R-values:
R R work R free
0.244 0.244 0.264
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
Xu et al. (2019)
3 more

11 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
10 more