Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147432 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Vascular endothelial growth factor receptor 2
Molecule details ›
Chain: R
Length: 772 amino acids
Theoretical weight: 86.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Length: 772 amino acids
Theoretical weight: 86.57 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P35968 (Residues: 1-764; Coverage: 56%)
Sequence domains:
- Vascular endothelial growth factor receptor 1-like, Ig-like domain
- Immunoglobulin domain
- Immunoglobulin I-set domain
- Immunoglobulin domain
N-VEGF
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 15.54 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines
Length: 134 amino acids
Theoretical weight: 15.54 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
- Canonical: P15692 (Residues: 207-320; Coverage: 29%)
Sequence domains: VEGF heparin-binding domain
Structure domains: Cystine-knot cytokines
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SLS BEAMLINE X06SA
Spacegroup:
P6522
Expression systems:
- Spodoptera frugiperda
- Komagataella pastoris
