› 3v4o

X-ray diffraction
2.1Å resolution

Human MALT1 (caspase domain) in complex with an irreversible peptidic inhibitor

Released:
DOI: 10.2210/pdb3v4o/pdb
PDB entry 3v4o coloured by chain, front view.
PDB entry 3v4o coloured by chain, side view.
PDB entry 3v4o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural determinants of MALT1 protease activity.
Wiesmann C, Leder L, Blank J, Bernardi A, Melkko S, Decock A, D'Arcy A, Villard F, Erbel P, Hughes N, Freuler F, Nikolay R, Alves J, Bornancin F, Renatus M
J Mol Biol 419 4-21 (2012)
PMID: 22366302

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-164150 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mucosa-associated lymphoid tissue lymphoma translocation protein 1 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 27.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9UDY8 (Residues: 329-569; Coverage: 29%)
Gene names: MALT1, MLT
Sequence domains: Caspase domain
Structure domains: Rossmann fold
MALT1 Inhibitor Chain: B
Molecule details ›
Chain: B
Length: 6 amino acids
Theoretical weight: 697 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P6122
Unit cell:
a: 77.5Å b: 77.5Å c: 180.493Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.179 0.176 0.228
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

10 review citations

A primer on caspase mechanisms.
Ramirez et al. (2018)
9 more

6 mentions without citation

The CBM signalosome: potential therapeutic target for aggressive lymphoma?
Yang et al. (2014)
5 more