› 3v83

X-ray diffraction
2.1Å resolution

The 2.1 angstrom crystal structure of diferric human transferrin

Released:
DOI: 10.2210/pdb3v83/pdb
PDB entry 3v83 coloured by chain, front view.
PDB entry 3v83 coloured by chain, side view.
PDB entry 3v83 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for iron piracy by pathogenic Neisseria.
Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK
Nature 483 53-8 (2012)
PMID: 22327295

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136222 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serotransferrin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 698 amino acids
Theoretical weight: 77.15 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02787 (Residues: 1-698; Coverage: 100%)
Gene names: PRO1400, TF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

4 bound ligands:
Ligand BCT 12 x BCT
Ligand FE 12 x FE
Ligand SO4 44 x SO4
Ligand P6G 14 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2
Unit cell:
a: 254.531Å b: 173.004Å c: 150.151Å
α: 90° β: 123.26° γ: 90°
R-values:
R R work R free
0.18 0.18 0.23

Quick links

Citations

39 review citations

Iron in infection and immunity.
Cassat et al. (2013)
38 more

28 mentions without citation

The transferrin-iron import system from pathogenic Neisseria species.
Noinaj et al. (2012)
27 more