› 3v8o

X-ray diffraction
2.8Å resolution

Human Filamin C Ig - like Domains 4 and 5

Released:
DOI: 10.2210/pdb3v8o/pdb
PDB entry 3v8o coloured by chain, front view.
PDB entry 3v8o coloured by chain, side view.
PDB entry 3v8o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel structural unit in the N-terminal region of filamins.
Sethi R, Seppälä J, Tossavainen H, Ylilauri M, Ruskamo S, Pentikäinen OT, Pentikäinen U, Permi P, Ylänne J
J Biol Chem 289 8588-98 (2014)
PMID: 24469451

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171988 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Filamin-C Chains: A, B
Molecule details ›
Chains: A, B
Length: 194 amino acids
Theoretical weight: 20.61 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14315 (Residues: 569-761; Coverage: 7%)
Gene names: ABPL, FLN2, FLNC
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 63.62Å b: 91.35Å c: 103.72Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.2 0.255
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Structure and Function of Filamin C in the Muscle Z-Disc.
Mao et al. (2020)
10 other articles

2 mentions without citation

A novel structural unit in the N-terminal region of filamins.
Sethi et al. (2014)
1 more