› 3vd2

X-ray diffraction
4Å resolution

structure of p73 DNA binding domain tetramer modulates p73 transactivation

Released:
DOI: 10.2210/pdb3vd2/pdb
PDB entry 3vd2 coloured by chain, front view.
PDB entry 3vd2 coloured by chain, side view.
PDB entry 3vd2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Ethayathulla AS, Tse PW, Monti P, Nguyen S, Inga A, Fronza G, Viadiu H
Proc Natl Acad Sci U S A 109 6066-71 (2012)
PMID: 22474346

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero octamer
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117050 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Tumor protein p73 Chains: A, B, C, D, I, J
Molecule details ›
Chains: A, B, C, D, I, J
Length: 210 amino acids
Theoretical weight: 23.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15350 (Residues: 115-312; Coverage: 31%)
Gene names: P73, TP73
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
DNA (5'-D(*AP*TP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*AP*T)-3') Chains: E, F, G, H, K, L
Molecule details ›
Chains: E, F, G, H, K, L
Length: 14 nucleotides
Theoretical weight: 4.28 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 6 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 158.4Å b: 91.127Å c: 137.475Å
α: 90° β: 90.2° γ: 90°
R-values:
R R work R free
0.258 0.248 0.284
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

7 review citations

How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.
Candi et al. (2014)
6 more

4 mentions without citation

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation.
Ethayathulla et al. (2012)
3 more