› 3vfq

X-ray diffraction
2.8Å resolution

Human PARP14 (ARTD8, BAL2) - macro domains 1 and 2 in complex with adenosine-5-diphosphoribose

Released:
DOI: 10.2210/pdb3vfq/pdb
PDB entry 3vfq coloured by chain, front view.
PDB entry 3vfq coloured by chain, side view.
PDB entry 3vfq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains.
Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B
Structure 21 462-75 (2013)
PMID: 23473667

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-175097 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP14 Chain: A
Molecule details ›
Chain: A
Length: 415 amino acids
Theoretical weight: 44.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N5 (Residues: 784-1196; Coverage: 23%)
Gene names: BAL2, KIAA1268, PARP14
Sequence domains: Macro domain
Structure domains: Leucine Aminopeptidase, subunit E, domain 1

Ligands and Environments

1 bound ligand:
Ligand AR6 1 x AR6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P2221
Unit cell:
a: 46.62Å b: 59.94Å c: 144.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.238 0.233 0.283
Expression system: Escherichia coli

Quick links

Citations

23 review citations

Structures and Mechanisms of Enzymes Employed in the Synthesis and Degradation of PARP-Dependent Protein ADP-Ribosylation.
Barkauskaite et al. (2015)
22 more

8 mentions without citation

Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
Camicia et al. (2015)
7 more