› 3vhu

X-ray diffraction
2.11Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140040 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mineralocorticoid receptor Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 34.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08235 (Residues: 712-984; Coverage: 28%)
Gene names: MCR, MLR, NR3C2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand SNL 1 x SNL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: C2221
Unit cell:
a: 91.526Å b: 171.509Å c: 42.358Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.246
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Nonsteroidal antagonists of the mineralocorticoid receptor.
Kolkhof et al. (2015)
3 more

6 mentions without citation

Structural protein-ligand interaction fingerprints (SPLIF) for structure-based virtual screening: method and benchmark study.
Da et al. (2014)
5 more