› 3vi5

X-ray diffraction
2Å resolution

Human hematopoietic prostaglandin D synthase inhibitor complex structures

Released:
DOI: 10.2210/pdb3vi5/pdb
PDB entry 3vi5 coloured by chain, front view.
PDB entry 3vi5 coloured by chain, side view.
PDB entry 3vi5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human hematopoietic prostaglandin D synthase inhibitor complex structures.
Kado Y, Aritake K, Uodome N, Okano Y, Okazaki N, Matsumura H, Urade Y, Inoue T
J Biochem 151 447-55 (2012)
PMID: 22418579

Function and Biology Details

Reactions catalysed: 
RX + glutathione = HX + R-S-glutathione
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130086 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hematopoietic prostaglandin D synthase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 198 amino acids
Theoretical weight: 23.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60760 (Residues: 2-199; Coverage: 100%)
Gene names: GSTS, HPGDS, PGDS, PTGDS2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
3 bound ligands:
Ligand CA 2 x CA
Ligand M4M 2 x M4M
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P1
Unit cell:
a: 47.277Å b: 48.986Å c: 91.919Å
α: 95.8° β: 90.99° γ: 90.14°
R-values:
R R work R free
0.179 0.176 0.249
Expression system: Escherichia coli

Quick links

Citations

2 citation in other articles

Suppression of Very Early Stage Of Adipogenesis by Baicalein, a Plant-Derived Flavonoid through Reduced Akt-C/EBPα-GLUT4 Signaling-Mediated Glucose Uptake in 3T3-L1 Adipocytes.
Nakao et al. (2016)
1 more