› 3vie

X-ray diffraction
1.8Å resolution

HIV-gp41 fusion inhibitor Sifuvirtide

Released:
DOI: 10.2210/pdb3vie/pdb
PDB entry 3vie coloured by chain, front view.
PDB entry 3vie coloured by chain, side view.
PDB entry 3vie coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide.
Yao X, Chong H, Zhang C, Waltersperger S, Wang M, Cui S, He Y
J Biol Chem 287 6788-96 (2012)
PMID: 22228771

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137979 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transmembrane protein gp41 Chains: A, C, E
Molecule details ›
Chains: A, C, E
Length: 37 amino acids
Theoretical weight: 4.15 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided
UniProt:
  • Canonical: P04578 (Residues: 546-581; Coverage: 4%)
Gene name: env
Sifuvirtide Chains: B, D, F
Molecule details ›
Chains: B, D, F
Length: 37 amino acids
Theoretical weight: 4.72 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 88.787Å b: 49.179Å c: 55.818Å
α: 90° β: 90.65° γ: 90°
R-values:
R R work R free
0.184 0.182 0.219
Expression system: Not provided

Quick links

Citations

9 review citations

Therapeutic peptides: current applications and future directions.
Wang et al. (2022)
8 more

6 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
5 more