› 3vkx

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146041 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Proliferating cell nuclear antigen Chain: A
Molecule details ›
Chain: A
Length: 261 amino acids
Theoretical weight: 28.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12004 (Residues: 1-261; Coverage: 100%)
Gene name: PCNA
Sequence domains:
Structure domains: Proliferating Cell Nuclear Antigen

Ligands and Environments

3 bound ligands:
Ligand T3 1 x T3
Ligand SO4 6 x SO4
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: I213
Unit cell:
a: 143.107Å b: 143.107Å c: 143.107Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.249
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Regulation of PCNA-protein interactions for genome stability.
Mailand et al. (2013)
21 more

13 mentions without citation

Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication.
Punchihewa et al. (2012)
12 more