› 3voq

X-ray diffraction
2Å resolution

Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit

Released:
DOI: 10.2210/pdb3voq/pdb
PDB entry 3voq coloured by chain, front view.
PDB entry 3voq coloured by chain, side view.
PDB entry 3voq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.
Pan D, Matsuura Y
Acta Crystallogr Sect F Struct Biol Cryst Commun 68 386-92 (2012)
PMID: 22505404

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189657 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Target of rapamycin complex 2 subunit MAPKAP1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BPZ7 (Residues: 372-493; Coverage: 23%)
Gene names: MAPKAP1, MIP1, SIN1
Sequence domains: SAPK-interacting protein 1 (Sin1), Pleckstrin-homology
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P43212
Unit cell:
a: 79.293Å b: 79.293Å c: 123.599Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.193 0.224
Expression system: Escherichia coli

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Citations

3 review citations

PI3K signaling in cancer: beyond AKT.
Lien et al. (2017)
2 more

8 mentions without citation

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.
Liu et al. (2015)
7 more