› 3w10

X-ray diffraction
2.7Å resolution

Aurora kinase A complexed to pyrazole aminoquinoline I

Released:
DOI: 10.2210/pdb3w10/pdb
PDB entry 3w10 coloured by chain, front view.
PDB entry 3w10 coloured by chain, side view.
PDB entry 3w10 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Oliveira TM, Kairies NA, Engh RA

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O14965 (Residues: 126-403; Coverage: 69%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand RO9 1 x RO9
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6122
Unit cell:
a: 89.95Å b: 89.95Å c: 164.302Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.246 0.309
Expression system: Escherichia coli

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