› 3w6p

X-ray diffraction
1.7Å resolution

Crystal structure of human Dlp1 in complex with GDP.AlF4

Released:
DOI: 10.2210/pdb3w6p/pdb
PDB entry 3w6p coloured by chain, front view.
PDB entry 3w6p coloured by chain, side view.
PDB entry 3w6p coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of GTPase domain fused with minimal stalks from human dynamin-1-like protein (Dlp1) in complex with several nucleotide analogues
Kishida H, Sugio S
CURR TOP PEPT PROTEIN RES. 14 67-77 (2013)

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-126277 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynamin-1-like protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 364 amino acids
Theoretical weight: 40.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00429 (Residues: 1-329, 337-736; Coverage: 49%)
Gene names: DLP1, DNM1L, DRP1
Sequence domains:
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

6 bound ligands:
Ligand GDP 2 x GDP
Ligand ALF 2 x ALF
Ligand MG 2 x MG
Ligand NA 2 x NA
Ligand CA 1 x CA
Ligand PG4 2 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P212121
Unit cell:
a: 51.41Å b: 109.13Å c: 128.73Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.214
Expression system: Escherichia coli

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