› 3w8l

X-ray diffraction
2.4Å resolution

Crystal structure of human CK2 in complex with inositol hexakisphosphate

Released:
DOI: 10.2210/pdb3w8l/pdb
PDB entry 3w8l coloured by chain, front view.
PDB entry 3w8l coloured by chain, side view.
PDB entry 3w8l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140.
Lee WK, Son SH, Jin BS, Na JH, Kim SY, Kim KH, Kim EE, Yu YG, Lee HH
Proc Natl Acad Sci U S A 110 19360-5 (2013)
PMID: 24218616

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 335 amino acids
Theoretical weight: 40.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand IHP 2 x IHP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: OTHER
Spacegroup: P21
Unit cell:
a: 70.141Å b: 56.568Å c: 95.542Å
α: 90° β: 96.14° γ: 90°
R-values:
R R work R free
0.235 0.235 0.248
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Structural analyses of inositol phosphate second messengers bound to signaling effector proteins.
Blind RD. (2020)
4 more

4 mentions without citation

Structural and functional insights into the regulation mechanism of CK2 by IP6 and the intrinsically disordered protein Nopp140.
Lee et al. (2013)
3 more