› 3w9y

X-ray diffraction
2.2Å resolution

Crystal structure of the human DLG1 guanylate kinase domain

Released:
DOI: 10.2210/pdb3w9y/pdb
PDB entry 3w9y coloured by chain, front view.
PDB entry 3w9y coloured by chain, side view.
PDB entry 3w9y coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the guanylate kinase domain from discs large homolog 1 (DLG1/SAP97).
Mori S, Tezuka Y, Arakawa A, Handa N, Shirouzu M, Akiyama T, Yokoyama S
Biochem Biophys Res Commun 435 334-8 (2013)
PMID: 23624197

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large homolog 1 Chain: A
Molecule details ›
Chain: A
Length: 200 amino acids
Theoretical weight: 23.4 KDa
Source organism: Homo sapiens
Expression system: Cell-free synthesis
UniProt:
  • Canonical: Q12959 (Residues: 712-904; Coverage: 21%)
Gene name: DLG1
Sequence domains: Guanylate kinase
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P6522
Unit cell:
a: 65.535Å b: 65.535Å c: 180.563Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.215 0.209 0.265
Expression system: Cell-free synthesis

Quick links

Citations

3 citation in other articles

Phospho-proteomic discovery of novel signal transducers including thioredoxin-interacting protein as mediators of erythropoietin-dependent human erythropoiesis.
Held et al. (2020)
2 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)