› 3wfn

X-ray diffraction
1.95Å resolution

Crystal Structure of Nav1.6 IQ motif in complex with apo-CaM

Released:
DOI: 10.2210/pdb3wfn/pdb
PDB entry 3wfn coloured by chain, front view.
PDB entry 3wfn coloured by chain, side view.
PDB entry 3wfn coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for the modulation of the neuronal voltage-gated sodium channel NaV1.6 by calmodulin.
Reddy Chichili VP, Xiao Y, Seetharaman J, Cummins TR, Sivaraman J
Sci Rep 3 2435 (2013)
PMID: 23942337

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144010 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-1; Sodium channel protein type 8 subunit alpha Chains: B, C, D, E
Molecule details ›
Chains: B, C, D, E
Length: 182 amino acids
Theoretical weight: 20.48 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP26 (Residues: 1-149; Coverage: 100%)
  • Canonical: Q9WTU3 (Residues: 1893-1914; Coverage: 1%)
Gene names: Calm, Calm1, Cam, Cam1, Nbna1, Scn8a
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P21
Unit cell:
a: 72.83Å b: 50.752Å c: 150.666Å
α: 90° β: 91.48° γ: 90°
R-values:
R R work R free
0.201 0.2 0.237
Expression system: Escherichia coli

Quick links

Citations

4 review citations

The many structural faces of calmodulin: a multitasking molecular jackknife.
Kursula P. (2014)
3 more

9 mentions without citation

Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.
Nathan et al. (2021)
8 more