› 3wge

X-ray diffraction
0.95Å resolution

Function and Biology Details

Reaction catalysed: 
Catalyzes the rearrangement of -S-S- bonds in proteins
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 113 amino acids
Theoretical weight: 13.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBS9 (Residues: 190-298; Coverage: 27%)
Gene names: TLP46, TXNDC5, UNQ364/PRO700
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P212121
Unit cell:
a: 32.58Å b: 39.06Å c: 87.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.123 0.122 0.135
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The Unfolded Protein Response and the Role of Protein Disulfide Isomerase in Neurodegeneration.
Perri et al. (2015)
8 more

2 mentions without citation

Functions and mechanisms of protein disulfide isomerase family in cancer emergence.
Rahman et al. (2022)
1 more