› 3wil

X-ray diffraction
2.9Å resolution

Crystal structure of the CK2alpha/compound3 complex

Released:
DOI: 10.2210/pdb3wil/pdb
PDB entry 3wil coloured by chain, front view.
PDB entry 3wil coloured by chain, side view.
PDB entry 3wil coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Kinoshita T, Nakanishi I

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159383 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase II subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 340 amino acids
Theoretical weight: 40.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68400 (Residues: 1-335; Coverage: 86%)
Gene names: CK2A1, CSNK2A1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LCD 1 x LCD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P212121
Unit cell:
a: 48.092Å b: 78.991Å c: 82.518Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.204 0.281
Expression system: Escherichia coli

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Citations

4 citation in other articles

Pharmacophore-based virtual screening, synthesis, biological evaluation, and molecular docking study of novel pyrrolizines bearing urea/thiourea moieties with potential cytotoxicity and CDK inhibitory activities.
Shawky et al. (2021)
3 more

1 mention without citation

Crystal structures of human CK2α2 in new crystal forms arising from a subtle difference in salt concentration.
Tsuyuguchi et al. (2018)