› 3wlw

X-ray diffraction
3.09Å resolution

Molecular Architecture of the ErbB2 Extracellular Domain Homodimer

Released:
DOI: 10.2210/pdb3wlw/pdb
PDB entry 3wlw coloured by chain, front view.
PDB entry 3wlw coloured by chain, side view.
PDB entry 3wlw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular architecture of the ErbB2 extracellular domain homodimer.
Hu S, Sun Y, Meng Y, Wang X, Yang W, Fu W, Guo H, Qian W, Hou S, Li B, Rao Z, Lou Z, Guo Y
Oncotarget 6 1695-706 (2015)
PMID: 25633808

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-209116 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (4 distinct):
Receptor tyrosine-protein kinase erbB-2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 564 amino acids
Theoretical weight: 62.19 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P04626 (Residues: 23-586; Coverage: 46%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Sequence domains:
Structure domains:
Antibody H Chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 217 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Antibody L Chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 217 amino acids
Theoretical weight: 23.09 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: P1
Unit cell:
a: 84.716Å b: 104.185Å c: 116.712Å
α: 106.89° β: 99.65° γ: 111.12°
R-values:
R R work R free
0.234 0.232 0.269
Expression system: Cricetulus griseus

Quick links

Citations

4 review citations

Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia.
Black et al. (2019)
3 more

6 mentions without citation

Molecular architecture of the ErbB2 extracellular domain homodimer.
Hu et al. (2015)
5 more