› 3wo2

X-ray diffraction
2.33Å resolution

Crystal structure of human interleukin-18

Released:
DOI: 10.2210/pdb3wo2/pdb
PDB entry 3wo2 coloured by chain, front view.
PDB entry 3wo2 coloured by chain, side view.
PDB entry 3wo2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structural basis for receptor recognition of human interleukin-18.
Tsutsumi N, Kimura T, Arita K, Ariyoshi M, Ohnishi H, Yamamoto T, Zuo X, Maenaka K, Park EY, Kondo N, Shirakawa M, Tochio H, Kato Z
Nat Commun 5 5340 (2014)
PMID: 25500532

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-18 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 157 amino acids
Theoretical weight: 18.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14116 (Residues: 37-193; Coverage: 81%)
Gene names: IGIF, IL18, IL1F4
Sequence domains: Interleukin-1 / 18
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand CPS 12 x CPS
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL38B1
Spacegroup: P21
Unit cell:
a: 68.146Å b: 79.511Å c: 73.46Å
α: 90° β: 100.97° γ: 90°
R-values:
R R work R free
0.221 0.218 0.271
Expression system: Escherichia coli

Quick links

Citations

22 review citations

Overview of the IL-1 family in innate inflammation and acquired immunity.
Dinarello CA. (2018)
21 more

12 mentions without citation

Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Xia et al. (2021)
11 more