Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Ets domain
- Acute myeloid leukemia 1 protein (AML1)/Runt
- Runt domain
- ETS family
- Winged helix DNA-binding domain superfamily
- Winged helix-like DNA-binding domain superfamily
- p53-like transcription factor, DNA-binding domain superfamily
- p53/RUNT-type transcription factor, DNA-binding domain superfamily
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117094 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Runt-related transcription factor 1
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.54 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: Runt domain
Structure domains: Immunoglobulin-like
Length: 123 amino acids
Theoretical weight: 13.54 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q03347 (Residues: 55-177; Coverage: 27%)
Sequence domains: Runt domain
Structure domains: Immunoglobulin-like
Protein C-ets-1
Molecule details ›
Chain: B
Length: 109 amino acids
Theoretical weight: 12.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Length: 109 amino acids
Theoretical weight: 12.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P14921 (Residues: 333-441; Coverage: 25%)
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
SPRING-8 BEAMLINE BL45PX
Spacegroup:
C2221
Expression system: Escherichia coli
