› 3wuz

X-ray diffraction
1.3Å resolution

Crystal structure of the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha

Released:
DOI: 10.2210/pdb3wuz/pdb
PDB entry 3wuz coloured by chain, front view.
PDB entry 3wuz coloured by chain, side view.
PDB entry 3wuz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.
Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K
Proc Natl Acad Sci U S A 111 8877-82 (2014)
PMID: 24889612

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paired immunoglobulin-like type 2 receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKJ1 (Residues: 32-150; Coverage: 42%)
Gene name: PILRA
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand IPA 1 x IPA
Ligand CIT 2 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 40.334Å b: 44.942Å c: 56.873Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.145 0.178
Expression system: Escherichia coli

Quick links

Citations

5 review citations

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.
Smith et al. (2021)
4 more

3 mentions without citation

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.
Rathore et al. (2018)
2 more