› 3wv0

X-ray diffraction
2.3Å resolution

O-glycan attached to herpes simplex virus type 1 glycoprotein gB is recognized by the Ig V-set domain of human paired immunoglobulin-like type 2 receptor alpha

Released:
DOI: 10.2210/pdb3wv0/pdb
PDB entry 3wv0 coloured by chain, front view.
PDB entry 3wv0 coloured by chain, side view.
PDB entry 3wv0 coloured by chain, top view.
Source organisms:
Primary publication:
Structural basis for simultaneous recognition of an O-glycan and its attached peptide of mucin family by immune receptor PILRα.
Kuroki K, Wang J, Ose T, Yamaguchi M, Tabata S, Maita N, Nakamura S, Kajikawa M, Kogure A, Satoh T, Arase H, Maenaka K
Proc Natl Acad Sci U S A 111 8877-82 (2014)
PMID: 24889612

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139045 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Paired immunoglobulin-like type 2 receptor alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UKJ1 (Residues: 32-150; Coverage: 42%)
Gene name: PILRA
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Envelope glycoprotein B Chains: X, Y
Molecule details ›
Chains: X, Y
Length: 7 amino acids
Theoretical weight: 610 Da
Source organism: Human alphaherpesvirus 1 strain KOS
Expression system: Not provided
UniProt:
  • Canonical: P06437 (Residues: 50-56; Coverage: 1%)
Gene names: UL27, gB

Ligands and Environments

Carbohydrate polymer : NEW Components: A2G, SIA
Carbohydrate polymer
1 bound ligand:
Ligand SO4 8 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2221
Unit cell:
a: 50.313Å b: 155.887Å c: 67.354Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.3
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

5 review citations

The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans.
Smith et al. (2021)
4 more

3 mentions without citation

Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease.
Rathore et al. (2018)
2 more