› 3wvz

X-ray diffraction
1.88Å resolution

Crystal structure of Hikeshi, a new nuclear transport receptor of Hsp70

Released:
DOI: 10.2210/pdb3wvz/pdb
PDB entry 3wvz coloured by chain, front view.
PDB entry 3wvz coloured by chain, side view.
PDB entry 3wvz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s.
Song J, Kose S, Watanabe A, Son SY, Choi S, Hong H, Yamashita E, Park IY, Imamoto N, Lee SJ
Acta Crystallogr D Biol Crystallogr 71 473-83 (2015)
PMID: 25760597

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Hikeshi Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 21.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53FT3 (Residues: 1-197; Coverage: 100%)
Gene names: C11orf73, HIKESHI, HSPC138, HSPC179, HSPC248
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2221
Unit cell:
a: 61.138Å b: 137.839Å c: 97.902Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.207 0.228
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Structural Biology and Regulation of Protein Import into the Nucleus.
Christie et al. (2016)
1 more

1 mention without citation

Absence of Hikeshi, a nuclear transporter for heat-shock protein HSP70, causes infantile hypomyelinating leukoencephalopathy.
Vasilescu et al. (2017)