› 3zd2

X-ray diffraction
1.99Å resolution

THE STRUCTURE OF THE TWO N-TERMINAL DOMAINS OF COMPLEMENT FACTOR H RELATED PROTEIN 1 SHOWS FORMATION OF A NOVEL DIMERISATION INTERFACE

Released:
DOI: 10.2210/pdb3zd2/pdb
PDB entry 3zd2 coloured by chain, front view.
PDB entry 3zd2 coloured by chain, side view.
PDB entry 3zd2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Dimerization of complement factor H-related proteins modulates complement activation in vivo.
Goicoechea de Jorge E, Caesar JJ, Malik TH, Patel M, Colledge M, Johnson S, Hakobyan S, Morgan BP, Harris CL, Pickering MC, Lea SM
Proc Natl Acad Sci U S A 110 4685-90 (2013)
PMID: 23487775

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169920 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement factor H-related protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 14.4 KDa
Source organism: Homo sapiens
Expression system: Kluyveromyces lactis
UniProt:
  • Canonical: Q03591 (Residues: 19-143; Coverage: 40%)
Gene names: CFHL, CFHL1, CFHL1P, CFHR1, CFHR1P, FHR1, HFL1, HFL2
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1

Ligands and Environments

1 bound ligand:
Ligand EDO 16 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 45.27Å b: 46.88Å c: 111.66Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.222 0.221 0.248
Expression system: Kluyveromyces lactis

Quick links

Citations

50 review citations

Complement System Part I - Molecular Mechanisms of Activation and Regulation.
Merle et al. (2015)
49 more

11 mentions without citation

The Factor H protein family: The switchers of the complement alternative pathway.
Lucientes-Continente et al. (2023)
10 more