› 3zeh

Solution NMR

Solution structure of the Hs. PSIP1 PWWP domain

Released:
DOI: 10.2210/pdb3zeh/pdb
PDB entry 3zeh coloured by chain, ensemble of 20 models, front view.
PDB entry 3zeh coloured by chain, ensemble of 20 models, side view.
PDB entry 3zeh coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain.
van Nuland R, van Schaik FM, Simonis M, van Heesch S, Cuppen E, Boelens R, Timmers HM, van Ingen H
Epigenetics Chromatin 6 12 (2013)
PMID: 23656834

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O75475 (Residues: 3-100; Coverage: 19%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: CYANA AND WATER-REFINEMENT IN CNS
Expression system: Escherichia coli BL21

Quick links

Citations

34 review citations

The interplay of histone modifications - writers that read.
Zhang et al. (2015)
33 more

3 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
2 more