› 3zfb

X-ray diffraction
1.86Å resolution

Crystal structure of the I75A mutant of human class alpha glutathione transferase in the apo form

Released:
DOI: 10.2210/pdb3zfb/pdb
PDB entry 3zfb coloured by chain, front view.
PDB entry 3zfb coloured by chain, side view.
PDB entry 3zfb coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Parbhoo N, Fanucchi S, Achilonu IA, Fernandes MA, Gildenhuys S, Dirr HW

Function and Biology Details

Reaction catalysed: 
RX + glutathione = HX + R-S-glutathione
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140083 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase A1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 25.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08263 (Residues: 1-222; Coverage: 100%)
Gene name: GSTA1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BRUKER X8 PROTEUM
Spacegroup: C2
Unit cell:
a: 99.869Å b: 91.681Å c: 51.249Å
α: 90° β: 93.05° γ: 90°
R-values:
R R work R free
0.228 0.224 0.285
Expression system: Escherichia coli BL21(DE3)

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