› 3zyq

X-ray diffraction
1.48Å resolution

Crystal structure of the tandem VHS and FYVE domains of Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS-Hrs) at 1.48 A resolution

Released:
DOI: 10.2210/pdb3zyq/pdb
PDB entry 3zyq coloured by chain, front view.
PDB entry 3zyq coloured by chain, side view.
PDB entry 3zyq coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Muniz JRC, Ayinampudi V, Shrestha L, Krojer T, Vollmar M, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Bullock A

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127226 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor-regulated tyrosine kinase substrate Chain: A
Molecule details ›
Chain: A
Length: 226 amino acids
Theoretical weight: 26.05 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O14964 (Residues: 1-225; Coverage: 29%)
Gene names: HGS, HRS
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand ZN 2 x ZN
Ligand SO4 1 x SO4
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Unit cell:
a: 38.256Å b: 34.346Å c: 170.533Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.164 0.215
Expression system: Escherichia coli BL21(DE3)

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