Function and Biology Details
Reactions catalysed:
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Probable formamidopyrimidine-DNA glycosylase (preferred)
PDBe Complex ID:
PDB-CPX-178382 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Probable formamidopyrimidine-DNA glycosylase
Molecule details ›
Chains: A, B
Length: 289 amino acids
Theoretical weight: 33.75 KDa
Source organism: Acanthamoeba polyphaga mimivirus
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 289 amino acids
Theoretical weight: 33.75 KDa
Source organism: Acanthamoeba polyphaga mimivirus
Expression system: Escherichia coli
UniProt:
- Canonical:
Q5UQ00 (Residues: 1-287; Coverage: 100%)
Sequence domains:
- Formamidopyrimidine-DNA glycosylase N-terminal domain
- Formamidopyrimidine-DNA glycosylase H2TH domain
- Formamidopyrimidine-DNA glycosylase C-terminal domain
